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This is further metabolized by microsomal epoxide hydrolase

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Studies show Alpha GPC can elevate acetylcholine levels in as little as 12 hours after intake[2 Trusted Source 1992 - International Journal of Clinical Pharmacology, Therapy, and Toxicology A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteers ]

They were also less likely to experience a documented opioid poisoning event over the study window, with 7% having such an event, versus 16% for those without a prescription (see Figure below)

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